Short Acting Beta-Agonist - Salbutamate 10%

Salbutamate 10% is used as a metabolic modifiers or repartitioning agents. The term "repartitioning agent" describes an agent that directs substrates away from fat deposition towards muscle accretion. Salbutamate 10% consists of R-salbutamol sulphate, a beta-2 (ß2) adrenergic agonist.

Why R-salbutamol?

Salbutamol consists of a 1:1 ratio of the R- and S-isomer. R-salbutamol is the pure isomer of salbutamol without the S-isomer. Salbutamol binds to both ß1 and ß2 receptors on body cells. S-salbutamol has a higher affinity for the ß1 receptor, while R-salbutamol is selective for the ß2 receptor. S-salbutamol also inhibit the activity of R-salbutamol. Therefore, the absence of S-salbutamol leads to improved receptor affinity and a shorter pharmacological half-life.

Implication of receptor affinity

ß1 receptors are present on the heart muscle and kidneys. Stimulation of the ß1 receptors leads to increased heart rate and tachycardia. ß2 receptors are present on the lungs, muscle and most importantly, fat (adipose) tissue. The absence of the S-isomer in Salbutamate 10% reduces the negative effect of heart palpitations.

Effect Salbutamate 10% on fat and muscle metabolism

R-salbutamol binds to the ß2 receptors present on fat, stimulating fat breakdown and increasing the amount of energy available for muscle growth.
With increased energy available for muscle growth, R-salbutamol also binds to ß2 receptors on the muscle, further increasing protein deposition, leading to carcass dressing percentage, improved carcass weight, improved feed conversion ratio and an overall increase in profitability.

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Salbutamate 10% Mode of Action